Stefania Orrù
Molecular effects induced by doping agents or physical exercise on biological systems and characterization of nanobiotechnological systems

Stefania Orrù


Stefania Orrù has got her Degree in Chemistry (1994) with full marks and honors and her PhD in Chemical Sciences (1999) at the University of Naples "Federico II". She carried out her research activity at the Biochemistry Department of Cambridge University (Cambridge, UK) from 1997 to 1998. She was a researcher at the Istituto di Ricerca di Biologia Molecolare (IRBM) “P. Angeletti” (Pomezia, Roma) from 1998 to 1999. She held a post-doc position at the University of Salerno from 1999 to 2003, and at University of Naples "Federico II", from 2004 to 2005. She was awarded a FEBS and an EMBO fellowship in 1997.

Since 2005, she is Associate Professor in 06N2 SSD M-EDF/01 (Methods and teaching of movement sciences) at the Department of Movement Sciences and Wellbeing, University of Naples "Parthenope".

Qualified for the Full Professor role in 06N2 (SSD M-EDF/01) and in 05E1 (SSD BIO-10).

She is member of the PhD board in "Sport and Movement Sciences", University of Naples "Parthenope" (XXX cycle-present).

She is Member of the Quality Assurance Board at the Department of Movement Sciences and Wellbeing, University of Naples "Parthenope" and member of the School of Science, Engineering and Health Board of the University of Naples "Parthenope”.

Member of the Italian Society of Sport and Movement Sciences (SISMeS) and member of the SISMeS Board (2018-2020).

Principal Investigator at CEINGE Biotecnologie Avanzate, Naples.

She authors more than 60 papers in peer reviewed journals and few book chapters.

Curriculum145.97 KB

The research activity carried out at CEINGE is focused on unraveling the molecular effects of doping agents (di-hydrotestosterone, DHT, and insuline-like growth factor 1, IGF-1) on biological systems and on defining the exercise-mediated serum/muscle molecular biomarkers associated with healthy longevity by means of structural, differential and functional proteomic approaches. Moreover, this PI and her research group is also involved in the analysis of biocompatible nanoparticles (i.e., liposomes) for drug delivery; such nanovectors are characterized at chemical/physical level (stability, size, polydispersity index and surface charge analysis), at biochemical level (identification of protein corona), and at biological level (up-take and cytotoxicity analysis).

PI’s research activity is expressed in about 60 articles published in peer-rewieved international journals and in some book chapters.

Research lines

The main topics of the research activity are:

  • Molecular effects of doping agents on biological systems
  • Exercise-mediated serum/muscle molecular biomarkers associated with healthy aging
  • Chemical/physical, biochemical and biological characterization of nanoparticles for drug delivery
  • Structural, functional and differential proteomic analysis in different physio-/pathological contexts
Research Group
  • Armando Cevenini, ricercatore BIO12 DMMBM (Univ. di Napoli “Federico II”)
  • Esther Imperlini, docente a contratto (Univ. Di Napoli “Partenope) e ricercatore a contratto (IRCCS SDN)
Most relevant publications
  1. Mancini A, Vitucci D, Randers MB, Schmidt JF, Hagman M, Andersen TR, Imperlini E, Mandola A, Orrù S, Krustrup P, Buono P. Lifelong football training: effects on autophagy and healthy longevity promotion. Frontiers Physiol (2019) in press.
  2. Imperlini E, Gnecchi M, Rognoni P, Sabidò E, Ciuffreda MC, Palladini G, Espadas G, Mancuso FM, Bozzola M, Malpasso G, Valentini V, Palladini G, Orrù S, Ferraro G, Milani P, Perlini S, Salvatore F, Merlini G, Lavatelli F. Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells. Sci. Rep. (2017) 7: 15661.
  3. Khaled SZ, Cevenini A, Yazdi IK, Parodi A, Evangelopoulos M, Corbo C, Scaria S, Hu Y, Haddix SG, Corradetti B, Salvatore F, Tasciotti E. One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA. Biomaterials (2016) 87: 57-68.
  4. Imperlini E, Spaziani S, Mancini A, Caterino M, Buono P, Orrù S. Synergistic effect of DHT and IGF-1 hyperstimulation in human peripheral blood lymphocytes. Proteomics. (2015) 15: 1813-1818.
  5. Imperlini E, Colavita I, Caterino M, Mirabelli P, Pagnozzi D, Del Vecchio L, Di Noto R, Ruoppolo M, Orrù S. The secretome signature of colon cancer cell lines. J Cell Biochem (2013) 114: 2577-2587.