Roberto Berni Canani
Immunonutrition: innovative strategies against food-induced diseases and obesity

Roberto Berni Canani


Prof. Dr.Roberto Berni Canani is internationally recognized as one of the leading researchers in the area of pediatric gastroenterology,  food induced diseases and nutrition. He received his MD and PhD degrees from Univ. of Naples Federico II, Naples, Italy. He is board certified in Pediatrics. Chief of the Pediatric Allergy Program at the Dept. of Translational Medical Science and founder of the ImmunoNutritionLab at CEINGE Advanced Biotechnologies, Univ. of Naples Federico II. He is author of more than 300 publications. His publications are widely quoted (>12000 citations as at January 2019). Of these 45 papers have been cited >100 times. H-index score 50. Associate editor of World Journal of Gastroenterology, Journal of Pediatric Gastroenterology and Nutrition, Journal of Gastroenterology and Hepatology Research, Allergies, International Journal of Autoimmune Disease & Therapy.He is member of many national scientific societies(Italian Society of Pediatrics, Italian Society of Pediatric Gastroenterology Hepatology and Nutrition, Italian Society of Pediatric Allergy and Immunology, Italian Society of Infectious Diseases, Italian Society of Pediatric Research). Vice-president of the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (2008-2012) and actual chief of the food-induced diseases working group (from 2014). He is member of the European Academy of Allergy and Clinical Immunology and of the European Society for Pediatric Gastroenterology Hepatology and Nutrition. Member of the European Laboratory for the Investigation of Food Indiced Diseases.He has obtained several scientific prizes for the research activity. Member of the Expert Panel (from 2011) and of the Dietetic products, Nutrition and Allergies Panel of the European Food Safety Authority (2012-2015). From 2013 he is enclosed in the list of Top 100 Italian Scientists of VIA-Academy ( 

Curriculum107.84 KB

The Team is highly interdisciplinary and composed by pediatricians, nutritionists, biologists, microbiologists, immunologists,  biostatisticians, and research nurses. 

The research activity is mainly focused on the study of basic and clinical aspects of: nutrition, gut microbiome structure and function, epigenome, pro-/pre-/sin/postbiotics, food allergy and intolerances, pediatric allergy,  obesity and obesity-related conditions, aiming to move disease biology from the laboratory to clinical practice with the development of innovative for the diagnosis, the prevention and the management of these conditions.

The basic science research activity is well integrated with the clinical research activity dedicated to several randomized controlled trial performed at national and international level.

Research lines
  1. Food induced diseases: food allergies and intolerances. Pathophysiology of immune tolerance. Genetic and epigenetic basis. Role of environmental factors. New tools for the diagnosis, prevention and managing. 
  1. Pediatric Allergy. Pathophysiology of immune tolerance. Genetic and epigenetic basis. Role of environmental factors. New tools for the diagnosis, prevention and managing. 
  1. Obesity and obesity-related disorders. Pathophysiological basis. Role of environmental factors and of epigenetic mechanisms. New strategies for prevention and treatment. 
  1. The immunonutrition approach as innovative strategy for the prevention and the treatment of infectious diseases using dietary factors, probiotics and postbiotics.
Research Group


Clinical Unit


  • L.Carucci, MD
  • L.Cosenza, MD
  • T.Cozzolino, MD
  • M.Di Costanzo, MD, PhD student
  • V.Giglio, RN
  • Y.Maddalena, MD
  • R.Nocerino, RN
  • G.Bedogni, MD, PhD


Basic Reasearch Unit

  • L. Paparo, BS, PhD
  • C. Bruno, BS, PhD student
  • V. Canale, BS
  • A. Sarracino, BS


Nutrition Unit

  • S.Coppola, RDN
  • G.Della Gatta, LDN, PhD student
  • C.Di Scala, LDN, PhD student
  • A. Luzzetti, LDN, PhD student
  • L.Voto, LDN, PhD student
Most relevant publications
  • Berni Canani R, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, Calignano A, Khan AA, Gilbert JA, Nagler CR. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME Journal 2016;10(3):742-50.
  • Berni Canani R, Di Costanzo M, Bedogni G, Amoroso A, Cosenza L, Di Scala C, Granata V, Nocerino R.Extensively hydrolyzed casein formula containing lactobacillus rhamnosus GG prevents the occurrence of other allergic manifestations in subjects with cow’s milk allergy: 3-year randomized controlled trial. Journal of Allergy and Clinical  Immunology 2017; 139(6): 1906-1913.e4.
  • D’Argenio V, Del Monaco V, Paparo L, De Palma FDE, Nocerino R, D’Alessio F, Visconte F, Discepolo V, Del Vecchio L, Salvatore F, Berni Canani R. Altered miR-193a-5p expression in children with cow’s milk allergy. Allergy 2018; 73(2):379-86.
  • Paparo L, Nocerino R, Bruno C, Di Scala C, Cosenza L, Bedogni G, Di Costanzo M, Mennini M, D’Argenio V, Salvatore F, Berni Canani R. Randomized controlled trial on the influence of dietary intervention on epigenetic mechanisms in children with cow’s milk allergy: the EPICMA study. Sci Rep 2019;9(1):2828.
  • Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, Campbell E, Aitoro R, Nocerino R, Paparo L, Andrade J, Antonopoulos DA, Berni Canani R,  Nagler CR.  Healthy infants harbor intestinal bacteria that protect against food allergy. Nature Medicine 2019;25(3):448-453.