Metabolomics
Head of the research line Development and optimization of analytical methods in quantitative proteomics and metabolomics
Scientific Coordinator of the Metabolomics Facility
Full Professor of Analytical Chemistry at the University of Naples Federico II
Professor Angela Amoresano is a Full Professor of Analytical Chemistry at the University of Naples Federico II. She is Head of the Mass Spectrometry Laboratory for Chemical Analyses in Proteomics and Quantitative Metabolomics at the Department of Chemical Sciences of the same university, as well as Head of the National Laboratory of Metabolomics and Proteomics of the I.N.B.B. Consortium (National Institute of Biostructures and Biosystems). More recently, she has also taken on the responsibility of the Metabolomics Facility at CEINGE, where she conducts research focused on the development and optimization of analytical methods for clinical, environmental, and agri-food applications.
Since 2013, she has been a member of the Faculty Board of the PhD Program in Chemical Sciences. She also serves on numerous selection committees for public recruitment procedures, involving the evaluation of qualifications and interviews, for the appointment of fixed-term researchers (RTDA), Associate Professors (PA), and Full Professors (PO) in the academic recruitment field 03/A1 – Analytical Chemistry.
Her research activity in biomolecular mass spectrometry dates back to 1993. Professor Amoresano has developed extensive expertise in the design of innovative, integrated analytical strategies that combine classical biochemical methodologies with advanced mass spectrometry techniques, including MS and MSⁿ, in both targeted and untargeted proteomics and metabolomics. Once developed and optimized, these analytical methods are applied to the identification and/or quantitative determination of target metabolites and proteins present at trace levels in complex biological matrices, enabling rapid multi-residue analyses.
The impact and quality of her scientific publications are reflected in the impact factors of the journals in which they appear, the number of citations, and an H-index of 46, as well as her participation in numerous national and international scientific conferences. She is the author of more than 290 publications in international peer-reviewed scientific journals in the fields of proteomics and metabolomics, which are available online.
Professor Amoresano has developed extensive expertise in the design and implementation of innovative, integrated analytical strategies for the qualitative and quantitative characterization of complex biological systems. Her research combines classical biochemical methodologies with advanced mass spectrometry techniques, including MS and tandem mass spectrometry (MSⁿ), with a primary focus on both targeted and untargeted proteomics and metabolomics. Particular emphasis is placed on the development and optimization of highly sensitive, selective, and robust analytical approaches. The methodologies developed are designed to support the identification, structural characterization, and quantification of proteins, peptides, and metabolites, including analytes present at trace levels in complex biological matrices. The integration of complementary sample preparation, separation, enrichment, and mass spectrometry-based analytical procedures addresses key challenges associated with matrix complexity, interfering compounds, and the need for accurate, reproducible measurements. A further research focus is the development of rapid, sensitive, and reliable multicomponent and multi-residue analytical methods for the investigation of biomolecules and metabolites of biological interest and their determination in complex samples. These integrated approaches enhance the analytical capabilities of mass spectrometry in biological research, supporting biomarker discovery, molecular profiling, and the investigation of the biochemical and metabolic mechanisms underlying biological processes.
Overall, Professor Amoresano’s research is characterized by the close integration of methodological innovation and bioanalytical applications. Its overarching goal is to develop advanced analytical tools that contribute to a deeper understanding of biological systems and enable the sensitive and selective characterization of molecular components in complex matrices.