Characterization of murine models and applied animal physiology
Head of the research line: Neurobiology of dystonia and gene-environment vulnerability
- Scientific Coordinator of the Animal Facility
- Responsible for Animal welfare
- Associate Professor of Veterinary Physiology – Department of Veterinary Medicine and Animal Production – University of Naples Federico II
Francesco Napolitano is an Associate Professor at the Department of Veterinary Medicine and Animal Productions of the University of Naples Federico II. His career is deeply rooted within CEINGE – Biotecnologie Avanzate Franco Salvatore. Having trained with a degree in Biological Sciences and a PhD in Neuroscience, carried out at the laboratory of professors Tommaso Russo and Nicola Zambrano, he spent about ten years as a postdoctoral researcher at the Translational Neuroscience laboratory, directed by Prof. Alessandro Usiello, consolidating his expertise in the field of behavioral and molecular neuroscience. Since 2017, Francesco Napolitano has held the role of Animal Welfare Officer at CEINGE and, since 2018, he has been the scientific coordinator of the Animal Facility. As a Principal Investigator, he is directly involved in the study and characterization of murine models of human and animal diseases by means of advanced technological platforms. These instruments range from tests for behavioural investigations (motor activity, social interaction, fear conditioning, anxiety, depression, sensorimotor gating, learning and memory, nociception) to multimodal imaging techniques (bioluminescence/fluorescence, fMRI, HFUS, and photoacoustic). Alongside basic research, he cultivates a deep scientific interest in the study of physiological processes related to the welfare of companion animals, as well as those of zootechnical interest.
- Neurobiology of dystonia and gene-environment vulnerability: Study of the pathogenetic mechanisms of hereditary generalized dystonia (DYT1/DYT-TOR1A). The research focuses on the "second hit" hypothesis, analyzing how early environmental stress factors act upon a latent genetic vulnerability (Tor1A mutation), triggering a breakdown of the excitatory/inhibitory (E/I) balance in the limbic (amygdala) and cortical circuits. This integrated approach (quantitative proteomics, ex vivo electrophysiology, high-field rs-fMRI, and behavioral tracking) aims to identify early biomarkers and new therapeutic targets to block behavioral dyscontrol and the maladaptive reorganization of limbic-motor networks.
- Applied physiology and animal welfare: Study of the role of bioactive fractions derived from buffalo whey in the regulation of the gut-brain axis. The research evaluates the efficacy of buffalo whey and its metabolic-proteomic components in restoring intestinal homeostasis, reducing neuroinflammation, and modulating the correlated behavioral and neurochemical alterations both in a murine model of induced intestinal dysbiosis and in veterinary clinical settings such as dogs affected by chronic enteropathy.
- Dr. Ciro Barile, DMV
- Dr. Domenico Sorrentino, PhD
- Dr. Fausta Caruso
- Valerio Abbondante
- Prof. Adelaide Greco, PhD, DMV
- Dr. Sandra Albanese
- Dr. Serena Monti, PhD
- Dr. Luca Licenziato, PhD, DMV
- Dr. Ernesto Soscia, MD