Decoding Heart Failure with Preserved Ejection Fraction and the Cardiometabolic Epidemic
Gabriele Schiattarella, professore di Cardiologia, alle ore 12.00 terrà un seminario dal titolo "Decoding Heart Failure with Preserved Ejection Fraction and the Cardiometabolic Epidemic".
Il professor Schiattarella è ordinario dell'Università Federico II di Napoli. Inoltre guida un gruppo di ricerca presso il Max Delbrück Center Molecular Medicine (MDC) di Berlino (Germania)
Introduce il professor Giovanni Esposito
Ospita il professor Pietro Forestieri
Abstract
Heart failure and metabolic disease – obesity, metabolic syndrome and diabetes – are epidemiologically and pathophysiologically intertwined. Their prevalence – collectively named cardiometabolic disease – is rising sharply worldwide. The mechanisms underlying the metabolic disturbances of the most common form of heart failure, heart failure with preserved ejection fraction (HFpEF) remain ill-defined. We focus on defining, at the cellular and molecular level, how alterations in metabolism, posttranslational modifications, and protein quality control modulate cardiac function and promote pathological cardiac remodeling and heart failure. Simply put, we asked the question: what are the metabolic drivers of cardiomyocyte dysfunction in HFpEF and related cardiometabolic disease? Through the employment of multiple experimental approaches, including in vivo and in vitro disease-modeling, we address these fundamental challenges directly.
* PER PARTECIPARE online:
https://us02web.zoom.us/j/85283018162?pwd=JjL6Due4hKy4lYrVHq2Lia8ULLvtkA.1
Meeting ID: 852 8301 8162
Passcode: 173376